Conditions
Cutaneous Squamous Cell Carcinoma, Endometrial Cancer, Solid Tumour
Trial Purpose
The purpose of this study is to evaluate pathological complete response (pCR) rate of coformulated favezelimab/pembrolizumab (MK-4280A) or pembrolizumab as assessed by blinded central pathology review (BICR) in participants with cutaneous squamous cell carcinoma (cSCC) [Cohort A] and to evaluate lenvatinib in combination with coformulated favezelimab/pembrolizumab or pembrolizumab with respect to objective response rate (ORR) per Response Evaluation Criteria in Solid Tumours (RECIST) 1.1 as assessed by investigator in participants proficient in mismatch repair (pMMR) endometrial cancer (EC) [Cohort B].
NATIONAL TRIAL REFERENCE NUMBER
NCT06036836
EU CT
2023-505022-34
When speaking to your doctor or clinical trial representative, please have the trial reference number available.
Resources
Eligibility
Only a qualified healthcare professional can determine if you are eligible to take part in a clinical trial. However, this information may be useful in starting a conversation with your doctor.
Age Range
18+
Sex
All
About The Trial
All patients who enroll in the trial will receive medication while on the study.
Cutaneous Squamous Cell Carcinoma (cSCC) Patients
50% will receive MK-4280A (contains favezelimab and pembrolizumab) before and after surgery.
50% will receive pembrolizumab before and after surgery.
Endometrial Cancer (EC) Patients
50% will receive MK-4280A (contains favezelimab and pembrolizumab) and lenvatinib.
50% will receive pembrolizumab and lenvatinib.
Trial Phase
Trial Phase 2
Tests the medicine or vaccine in approximately 100 to 500 volunteers. In the case of medicines, volunteers usually have the disease or condition the investigational medicine is designed to treat. In vaccine studies, the volunteers are usually healthy.
Trial start and end dates
- Actual study start date 29 September 2023
- Estimated primary completion date 9 March 2027
- Estimated study completion date 9 March 2027
Trial locations
Locations shown may have changed in some cases. Please call the number listed in the location results to confirm the nearest trial site. Talk with a trial site member for more information.
What can you do next?
If you think this clinical trial might be a good fit and you are interested in taking part, take the next step to see if you are eligible.
Taking part in a clinical trial is an important decision
If you are considering joining a clinical trial, first learn as much as you can about:
- The investigational treatment that is being studied
- What the risks and possible benefits are for participants
Talk to your doctor about the clinical trial before you decide to join.
Read our “What to Consider” page for more questions to ask and think about